A non-invasive neuromodulation technology that uses focused ultrasound pulses to reach and stimulate deep brain structures, with CE marking for the treatment of Alzheimer’s disease.
Transcranial Pulse Stimulation (TPS) is a neuromodulation technology that delivers short, focused ultrasound pulses through the skull to stimulate specific brain regions. Unlike transcranial magnetic stimulation (TMS) or transcranial direct current stimulation (tDCS), TPS can reach deep brain structures including the hippocampus, which plays a central role in memory and is affected early in Alzheimer’s disease.
TPS received CE marking in Europe for the treatment of Alzheimer’s disease and is used at St. George Hospital as part of comprehensive neurological treatment programs.
TPS generates low-energy, focused ultrasound pulses that are applied to the scalp through a handheld applicator guided by neuronavigation based on the patient’s MRI. The pulses pass through the skull and stimulate brain tissue through mechanotransduction — the conversion of mechanical energy into biological signals.
This stimulation activates neuroprotective pathways, promotes the release of brain-derived neurotrophic factor (BDNF), enhances synaptic plasticity, and improves regional cerebral blood flow. The neuronavigation system ensures precise targeting of the intended brain regions during each session.
TPS treatment requires neuroimaging (MRI) for neuronavigation. Our specialists will evaluate whether this therapy is appropriate based on your neurological assessment.
A TPS session lasts approximately 30 minutes. The patient sits comfortably while the physician applies the handheld TPS device to different areas of the scalp, guided by a real-time neuronavigation screen. Most patients feel a gentle tapping sensation during the treatment. The procedure is painless and requires no anesthesia or sedation. A standard course consists of 6 sessions over 2 weeks, though protocols may be adjusted based on individual response.
TPS has been studied in clinical trials at major European research centers. Published studies in journals including Alzheimer’s Research & Therapy and Brain Stimulation demonstrate improvements in cognitive function and brain network connectivity in Alzheimer’s patients. The treatment has a favorable safety profile with no serious adverse events reported in clinical trials. Mild, transient side effects may include headache or scalp sensitivity.
Contact our neuromodulation team to discuss whether transcranial pulse stimulation may benefit your neurological condition.
